Matrine is an alkaloid isolated from the medicinal plant Sophora flavescens Ait (Leguminosae) with various pharmacological and physiological effects. Here, we investigate its combined effects with imatinib, a specific tyrosine kinase inhibitor used clinically against leukemia cells, on bcr/abl-positive leukemia K562 cells. The results indicate that matrine enhanced imatinib-induced apoptosis in K562 cells through downregulation of protein levels of bcr/abl and phospho-Erk1/2.
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Liu et al. (2006) studied this question.
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