A metastatic granulosa-theca cell tumor of the ovary was studied by electron microscopy for the first time. The tumor cells showed cytoplasmic features similar to those of nonmalignant granulosa cells. Marked nuclear alterations, corresponding to the appearance of embryonic granulosa cells, were present. Cells varying in shape from round to elongated were otherwise identical in terms of cytoplasmic architecture and nuclear abnormalities. The significance of ultrastructural abnormalities in evaluating granulosa-theca cell tumors is discussed.
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Bernard Gondos (1969) studied this question.
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