Key result
Dual-sequence perfusion MRI preserves LV blood signal with negligible T2 signal loss during peak bolus.
Observational (n=10)
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PURPOSE: To examine whether T2* effects reduce the accuracy of arterial input function (AIF) measurement by the dual-sequence method. MATERIALS AND METHODS: The dual-sequence method obtains a low-resolution AIF image and high-resolution myocardial images in each cycle, with suitable T1 weightings. It was modified to assess T2* effects in the low-resolution AIF image (4.8x4.8x10 mm voxels, TE=0.58 msec) by minimizing T1 weighting in that sequence, while the myocardial sequence remained T1-weighted. In 10 patients who underwent perfusion MRI scans (0.5 M Magnevist, 0.1 mmol/kg, 15-ml flush, 7 mL/second right antecubital) the blood signal in the left ventricle (LV) was measured at the bolus peak and compared with the first cycle's fresh magnetization signal. RESULTS: The bolus peak measured 98%+/-4% (mean+/-SD, N=20) of the value before contrast agent arrival. CONCLUSION: T2* causes insignificant error in the dual-sequence method at the stated parameters.
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Gatehouse et al. (2006) conducted an observational in Myocardial perfusion evaluation (n=10). Modified dual-sequence perfusion MRI with 0.5 M Magnevist vs. First cycle fresh magnetization signal before contrast arrival was evaluated on Left ventricular blood signal at bolus peak relative to fresh magnetization signal before contrast arrival. T2 effects in dual-sequence perfusion MRI caused insignificant error, with the bolus peak LV blood signal measuring 98%±4% of the pre-contrast value.
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