Why the study?
Does a truncated cardiac troponin T mutation alter the regulatory properties of the thin filament in an in vitro model of familial hypertrophic cardiomyopathy?
Population
In vitro model using human cardiac troponin T overexpressed in Escherichia coli, purified, and combined with…
Comparison
Truncated mutant human cardiac troponin T vs Wild-type human cardiac troponin T
Design
Preclinical
Authors
Loading...
Dominant-negative troponin T effects shown in vitro; leaves open translation to human familial hypertrophic cardiomyopathy.
Does a truncated cardiac troponin T mutation alter the regulatory properties of the thin filament in an in vitro model of familial hypertrophic cardiomyopathy?
The truncated troponin T mutation associated with familial hypertrophic cardiomyopathy prevents switching off of the thin filament at low calcium levels, demonstrating its dominant-negative functional consequences.
Redwood et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: