Effect of antacids on pH of urine

To determine the effect of regular administration of usual doses of several antacids for 7 day periods on urine pH, measurements of urine pH were carried out daily on 11 healthy subjects during regular use of antacids and during control periods. On the average, suspensions of aluminum hydrOXide and dihydroxyaluminum glycinate had no significant effect on urine pH. Magnesium hydroxide and calcium carbonate‐glycine suspension increased urine pH by 0.4 to 0.5 U, while aluminum and magnesium hydroxide suspension increased pH by 0.9 U. The increase in urine pH was inversely proportional to the urine pH during the control periods. Regular administration of certain antacids can increase urine pH sufficiently to have pronounced effects on the kinetics of elimination of certain acidic and basic drugs.