January 1, 2002Cardiology
Grade III Ischemia on Presentation with Acute Myocardial Infarction Predicts Rapid Progression of Necrosis and Less Myocardial Salvage with Thrombolysis
Why the study?
Does baseline grade III ischemia predict rapid progression of necrosis and less myocardial salvage compared to grade II ischemia in patients with acute myocardial infarction treated with thrombolysis?
Population
49 patients with acute myocardial infarction who underwentTc sestamibi single-photon emission computed…
Comparison
Grade III ischemia on presentation vs Grade II ischemia on presentation
Design
Cohort
Follow-up
6 +/- 1 days
Authors
Discussion
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Member takes
Implication
Grade III ischemia signals faster necrosis in untreated AMI; leaves open differential thrombolytic salvage and needs prospective validation.
Structured PICO
Does baseline grade III ischemia predict rapid progression of necrosis and less myocardial salvage compared to grade II ischemia in patients with acute myocardial infarction treated with thrombolysis?
P
Population
49 patients with acute myocardial infarction who underwent (99m)Tc sestamibi single-photon emission computed tomography before and 6 +/- 1 days after thrombolysis
I
Intervention
Grade III ischemia on presentation (ST segment elevation with terminal QRS distortion, n=19)
C
Comparator
Grade II ischemia on presentation (ST elevation but no terminal QRS distortion, n=30)
O
Outcome
Initial myocardial area at risk (AR), final infarct size (IS), and infarction index (IS/AR ratio x100)surrogate
Grade III ischemia on presentation with acute myocardial infarction predicts more rapid progression of necrosis and less myocardial salvage with thrombolysis compared to grade II ischemia.
Cite This Study
Birnbaum et al. (2002) studied this question.