⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 5, 2026Transfusion

Apparent reduction of anti‐ FXa activity after 4F ‐ PCC Administration: True reversal or PCC ‐related analytical effect?

Gabor Erdoes Andreas Koster Ingvild Birschmann

View at Publisher

Ask AI

Bookmark

Share

Key Points

This research aims to determine if the apparent reduction in anti-FXa activity after 4F-PCC administration reflects true reversal or an analytical effect.
Evaluated anti-FXa activity following administration of 4F-PCC.
Assessed potential analytical effects influencing observed results.
Observed decrease in anti-FXa activity post 4F-PCC administration was apparent.
Further analysis is needed to confirm if this reduction represents true drug reversal or analytical bias.

Implication

Investigates the effects of 4F-PCC on FXa activity, suggesting implications for anticoagulant reversal.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Erdoes et al. (2026) studied this question.

synapsesocial.com/papers/6a76daf2f12abadc79815b3f https://doi.org/10.1111/trf.70351

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Impact of <scp>GLP</scp> ‐1 Receptor Agonist Discontinuation on Liver‐Related Parameters: A Systematic Review and Meta‐AnalysisSystematic Review · 2026
2Management of direct factor Xa inhibitor–related major bleeding with prothrombin complex concentrate: a meta-analysismeta-analysis · 2019 · 125 citations
3Utilization of 4-Factor Prothrombin Complex Concentrate for Reversal of Oral Factor Xa Inhibitor–Associated Acute Major Bleeding: A Case Seriescase_series · 2020 · 15 citations
4Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitorscohort · 2018 · 69 citations
5Andexanet versus prothrombin complex concentrates: Differences in reversal of factor Xa inhibitors in in vitro thrombin generationpreclinical · 2020 · 38 citations

Emergency reversal of pentasaccharide anticoagulants: a systematic review of the literature2011
P0684Rethinking the Dose: A Bayesian Meta-Analysis of Infliximab Intensification in Acute Severe Ulcerative Colitis2026
A Low-Dose 4F-PCC Protocol for DOAC-Associated Intracranial Hemorrhage2019
Prophylactic oral calcium–vitamin D3 –magnesium supplementation reduced citrate‐related reactions during peripheral blood stem cell collection in healthy donors: A randomized controlled trialTransfusion · 2026
Shelf‐life of cord blood red cell concentrates: Comparison of two additive solutionsTransfusion · 2026

More from Transfusion

More from Brandenburg University of Technology Cottbus-Senftenberg

More from Heart and Diabetes Center North Rhine-Westphalia

More from Spitalzentrum Centre hospitalier Biel- Bienne