Fatal differentiation syndrome-associated myocarditis caused by PML: RARα -positive neutrophils in acute promyelocytic leukemia

Somi Ozaki; Kotaro Miyao; Sohei Yamamoto; T. Wakayama; Masaya Numata; Kenta Motegi; H Sawa; Toshiyasu Sakai; Yuichiro Inagaki; Masashi Sawa

doi:10.1080/10428194.2026.2714599

August 6, 2026Leukemia & lymphoma/Leukemia and lymphoma

Fatal differentiation syndrome-associated myocarditis caused by PML: RARα -positive neutrophils in acute promyelocytic leukemia

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Key Points

The research aims to investigate the link between differentiation syndrome and myocarditis in patients with Acute Promyelocytic Leukemia treated with all-trans retinoic acid.
Analyzed clinical cases of patients diagnosed with Acute Promyelocytic Leukemia.
Focused on the role of neutrophils and their relation to differentiation syndrome and myocarditis.
Identified a significant association between ATRA treatment and increased incidences of myocarditis.
Highlighted that PML: RARα-positive neutrophils contribute to the development of differentiation syndrome.

Implication

Examines myocarditis outcomes in Acute Promyelocytic Leukemia treatments, indicating a serious complication from therapy.

Abstract

All-trans retinoic acid (ATRA) is an established first-line treatment for newly diagnosed Acute Promyelocytic Leukemia (APL) with high remission rates. However, differentiation syndrome (DS) remain...

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Cite This Study

Ozaki et al. (2026) studied this question.

synapsesocial.com/papers/6a76daf2f12abadc79815be2 https://doi.org/10.1080/10428194.2026.2714599

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Fatal differentiation syndrome-associated myocarditis caused by PML: RARα -positive neutrophils in acute promyelocytic leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

Fatal differentiation syndrome-associated myocarditis caused by PML: RARα -positive neutrophils in acute promyelocytic leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

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