Why the study?
How does the application of the revised Ghent criteria affect the diagnosis in an established adult Marfan syndrome population?
How does the application of the revised Ghent criteria affect the diagnosis in an established adult Marfan syndrome population?
The revised Ghent criteria for Marfan syndrome may underestimate aortic root dilatation in adults with large body surface areas, leading to rejected diagnoses in 9% of previously established patients.
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Revised Ghent criteria may reject Marfan diagnoses in large-BSA adults; leaves open whether Z-score thresholds require body-size adjustment.
Radonic et al. (2011) studied this question.
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