A Precise Method for Linking Neuroanatomy to Function After Stroke: A Pilot Study

PURPOSE: We examined the hypotheses that a comprehensive method for categorizing specific brain regions impaired by stroke is feasible and that this method may be used to explore associations between specific impaired brain regions and functional outcomes. METHOD: Impaired brain regions were identified with neuroanatomical diagrams. Body function outcomes (motor, somatosensory, and cognition) were measured with the National Institutes of Health Stroke Scale and activity outcomes (functional mobility, self-care, and instrumental activities of daily living) were measured with the Performance Assessment of Self-care Skills. Decision analyses identified brain regions associated with functional outcomes and the influence of ischemia on outcome scores. RESULTS: Motor control and somatosensation brain regions were linked with motor and somatosensory outcomes; those associated with decision making and motor planning were linked with cognition and functional mobility outcomes. Data were insufficiently powered to examine brain regions associated with self-care and instrumental activities of daily living outcomes. CONCLUSION: The findings support the feasibility of study methods. Further investigation with larger, well-defined samples is warranted using study methods.