Phenolic extracts from various Algerian plants as strong inhibitors of porcine liver carboxylesterase

Carboxylesterases (CE), expressed at high levels in human liver and intestine, are thought to detoxify xenobiotics. The goal of this study was to study the effect of phenolic compounds from several plants from the Algerian Atlas used traditionally in Arab folk medicine on the enzymatic activity of porcine liver carboxylesterase. The plants have shown a potent inhibition of carboxylesterase (CE) enzymatic activity in a concentration-dependent manner. Results indicate that the Phenolic extracts from these plants lead to the inactivation of the CE pI = 5.1 with K(i) values in micromolar range (1.4-38 microM). These results encourage further biological investigation and identification the inhibitors responsible for this activity.