What question did this study set out to answer?

To identify evidence of diffuse myocardial fibrosis in patients with dilated cardiomyopathy by comparing late gadolinium enhancement cardiovascular magnetic resonance metrics against healthy controls.

October 23, 2009Journal of Magnetic Resonance ImagingOpen Access

Shorter difference between myocardium and blood optimal inversion time suggests diffuse fibrosis in dilated cardiomyopathy

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Why the study?

Does LGE-CMR imaging reveal differences in blood-myocardium inversion time and contrast-to-noise ratio suggestive of diffuse fibrosis in patients with dilated cardiomyopathy compared to healthy controls?

Key Points

To identify evidence of diffuse myocardial fibrosis in patients with dilated cardiomyopathy by comparing late gadolinium enhancement cardiovascular magnetic resonance metrics against healthy controls.
Analyzed late gadolinium enhancement cardiovascular magnetic resonance and Look-Locker imaging datasets from 20 dilated cardiomyopathy patients and 17 healthy controls.
Measured blood and myocardial signal-to-noise ratios, blood-to-myocardium contrast-to-noise ratio, and optimal inversion times to estimate postcontrast T1.
Dilated cardiomyopathy patients had significantly lower blood-to-myocardium contrast-to-noise ratio compared to controls (6.6 ± 0.7 vs. 10.3 ± 0.9, P = 0.004).
The blood-myocardium optimal inversion time difference was significantly reduced in dilated cardiomyopathy (38 ± 2 msec vs. 55 ± 3 msec, P < 0.001), as was the estimated T1 difference (116 ± 6 msec vs. 152 ± 8 msec, P = 0.001).

Structured PICO

Population

20 patients with dilated cardiomyopathy (DCM) and 17 healthy controls

Intervention

Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) and Look-Locker imaging

Comparator

Healthy controls undergoing the same imaging protocol

Outcome

Blood-to-myocardium contrast-to-noise ratio (CNR) and blood-myocardium optimal inversion time difference (DeltaTI)surrogate

Reduced blood-myocardium inversion time difference and contrast-to-noise ratio on LGE-CMR suggest the presence of diffuse fibrosis in dilated cardiomyopathy patients.

Discussion

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Implication

Lower TI difference and CNR may indicate diffuse fibrosis in DCM; hypothesis-generating and requires validation before clinical adoption.

Cite This Study

Han et al. (2009) studied this question.

synapsesocial.com/papers/6a76e5820c6965f1a01e7ac2 https://doi.org/10.1002/jmri.21953

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Shorter difference between myocardium and blood optimal inversion time suggests diffuse fibrosis in dilated cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Shorter difference between myocardium and blood optimal inversion time suggests diffuse fibrosis in dilated cardiomyopathy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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