Key result
Psoriasis is linked to cardiovascular disease and metabolic syndrome via systemic inflammation.
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A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.
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Furue et al. (2017) conducted a review in Psoriasis, cardiovascular diseases, and metabolic syndrome. Psoriasis (systemic inflammation driven by the TNF-α/IL-23/IL-17A axis) was evaluated on Cardiovascular diseases and metabolic syndrome. Psoriasis has a prevalence of 0.1-0.5% in Asians and is significantly associated with cardiovascular diseases and metabolic syndrome through TNF-α/IL-23/IL-17A-driven systemic inflammation.
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