Skeletal Muscle Coenzyme A Transferase

The kinetic properties of a succinyl-CoA:3-oxo-acid-CoA transferase partially purified from bovine skeletal muscle were studied to provide a basis for assessing its physiological function. A number of metabolites were investigated as potential modifiers of the enzymatic activity with negative results. Kinetic results are consistent with preferred utilization of acetoacetate by the heart at low concentrations and an increased utilization by skeletal muscle during ketonemia.