Population
Isolated perfused lungs of guinea pigs, isolated perfused kidneys of rabbits, and in vivo dog models
Design
Preclinical
Authors
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Supports ANF as a circulating hormone targeting the kidney; hypothesis-generating and should not inform clinical practice.
Atrial natriuretic factor survives pulmonary transit but is largely extracted by the renal circulation, supporting its role as a circulating hormone targeting the kidney.
Weselcouch et al. (1985) studied this question.
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