Key result
Morbidly obese patients had significantly thicker corneas (p=0.013) and significant loss of hexagonality (p=0.012) compared with healthy controls, with no significant difference in cell density.
Why the study?
To evaluate morphological changes in corneal endothelial cells associated with morbid obesity and analyze the relationship between BMI and corneal endothelial features.
Does morbid obesity affect corneal endothelium morphology compared to healthy controls?
Case-Control
Does morbid obesity affect corneal endothelium morphology compared to healthy controls?
p-value: p=0.013
Morbid obesity is associated with thicker corneas and loss of hexagonality in corneal endothelial cells, though these changes do not correlate linearly with BMI.
Morbid obesity was associated with corneal changes; hypothesis-generating and should not yet change practice or screening.
Aims: To evaluate the morphological changes in corneal endothelial cells with morbid obesity, and to analyze the relationship between BMI and corneal endothelial features. Methods: The central corneal thickness (CCT), the average endothelial cell density (ECD) (cell/mm²), average cell area (CA) (µm²), coefficient of variation of cell area (CV)- (CV: Standard deviation/CA) values were recorded via specular microscopy in morbidly obese patients and controls. The whole parameters were compared. Results: The morbid obese patients had significantly thicker corneas (p=0.013), and significant loss of hexagonality (p=0.012) compared with controls, while there was no significant difference in ECD (p=0.311), CA (p=0.292), and CA (p=0.161). In linear regression analysis, there was no significant correlation between CCT, abdominal circumference, and the endothelium parameters. Conclusion: Although BMI has the effect of changing corneal morphology, this change is not correlated with an increase in BMI.
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Vural et al. (2023) conducted a case-control in Morbid obesity. Morbid obesity vs. Healthy controls was evaluated on Central corneal thickness (CCT) and hexagonality (p=0.013). Morbidly obese patients had significantly thicker corneas (p=0.013) and significant loss of hexagonality (p=0.012) compared with healthy controls, with no significant difference in cell density.
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