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The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring‐closing metathesis reaction involving fluoride‐substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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Matteis et al. (2006) studied this question.
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