ATP-sensitive and calcium-dependent potassium channels are key mediators of cerebral vasodilatation, and their dysfunction may contribute to vascular pathology in diseases like hypertension and diabetes.
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Does not support immediate clinical use; leaves open therapeutic targeting of these channels in hypertension, diabetes, and subarachnoid haemorrhage.
Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. 2. In cerebral blood vessels, two potassium channels have received considerable study recently: ATP-sensitive and calcium-dependent potassium channels. Activation of these potassium channels appears to play a major role in the relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor-mediated agonists, intracellular second messengers, reactive oxygen species and hypoxia. 3. The functional influence of ATP-sensitive and calcium-dependent potassium channels may be altered in disease states, including hypertension, diabetes and subarachnoid haemorrhage.
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Faraci et al. (1996) studied this question.
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