Molecular Detection of Enteroviruses from an Outbreak of Hand, Foot and Mouth Disease in Malaysia in 1997

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Structured PICO

Population

47 suspected hand, foot and mouth disease (HFMD) patients during an outbreak with incidences of fatal brainstem encephalomyelitis in Malaysia in 1997

Intervention

Molecular detection (RT-PCR) and genetic/phylogenetic analyses of Enterovirus 5'UTR sequences

Outcome

Detection and identification of enterovirus strainssurrogate

EV71 was identified as the specific enterovirus strain responsible for fatal brainstem encephalomyelitis during the 1997 HFMD outbreak in Malaysia.

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EV71 linked to all fatal HFMD cases here; leaves open whether strain typing should guide outbreak response.

Sazaly AbuBakar (1999) studied this question.

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