We describe herein the atroposelective formal synthesis of (–)‐steganone, a parent member of Steganotaenia araliacea dibenzocyclooctadiene lignan lactones. Our synthesis features an atropodiastereoselective biaryl Suzuki–Miyaura cross‐coupling reaction with de up to 99 % using as a chiral auxiliary an enantiopure and efficiently converted β‐hydroxy sulfoxide derivative.
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Yalcouye et al. (2014) studied this question.