Key result
High-sensitivity troponin levels do not differ across arteriogenic and nonarteriogenic erectile dysfunction subtypes.
Why the study?
Does the measurement of high-sensitivity troponin reveal early cardiac injury in men with recent-onset erectile dysfunction?
Cross-Sectional (n=120)
No
Does the measurement of high-sensitivity troponin reveal early cardiac injury in men with recent-onset erectile dysfunction?
High-sensitivity troponin levels are within normal ranges in men with recent-onset erectile dysfunction without atherosclerotic risk factors, suggesting no early cardiac involvement.
Hs-troponin levels within normal range do not detect early cardiac injury in recent-onset ED; hypothesis-generating for screening utility.
BACKGROUND: Evidence is accumulating in favour of a link between erectile dysfunction (ED) and coronary artery diseases. We investigated the presence of cardiac injury in patients who have had arteriogenic and nonarteriogenic ED using the hs-Tn levels. METHODS: The diagnosis of ED was based on the International Index of Erectile Function 5-questionnaire (IIF-5) and patients were classified as arteriogenic (A-ED, n = 40), nonarteriogenic (NA-ED, n = 48), and borderline (BL-ED, n = 32) patients in relation to the results of echo-color-Doppler examination of cavernous arteries. The level of hs-TnT and hs-TnI was measured in 120 men with a history of ED of less than one year with no clinical evidence of cardiac ischemic disease. RESULTS: The levels of both hs-TnT and hs-TnI were within the reference range and there was no significant (P > 0.05) difference between patients of the three groups. The hs-CRP values were higher in A-ED men compared with NA-ED (P = 0.048) but not compared with BL-ED (P = 0.136) and negatively correlated with IIF-5 (r = -0.480; P = 0.031). CONCLUSIONS: In ED patients of the three groups the measurement of hs-Tn allows us to exclude the presence of cardiac involvement at least when the history of ED is less than one year and the men are without atherosclerotic risk factors.
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Barassi et al. (2015) conducted a cross-sectional in Erectile dysfunction (n=120). Arteriogenic erectile dysfunction (A-ED) vs. Nonarteriogenic (NA-ED) and borderline erectile dysfunction (BL-ED) was evaluated on Serum concentrations of high-sensitivity troponin T (hs-TnT) and troponin I (hs-TnI) (p=>0.05). High-sensitivity troponin T and I levels remained within the normal reference range with no significant differences (P > 0.05) among men with arteriogenic, nonarteriogenic, and borderline ED.
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