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In unanesthetized decerebrate cats the effect of monoamine blockers has been investigated on the decerebrate tonic inhibitory control of transmission from the FRA (flexor reflex afferents) to motoneurones. No certain effect is obtained after injection of phenoxybenzamine but S‐hydroxytryptamine antagonists (BOL or Deseril) give a partial release from the tonic descending control of transmission from the FRA. The monoamine oxidase inhibitor, nialamide, increased the effectiveness of the tonic control. The tonic decerebrate control may in part remain after complete destruction of the raphae nuclei. It is tentatively suggested that a 5‐hydroxytryptaminergic pathway descending from the raphae nuclei may contribute to, but probablv is not solely responsible for, the tonic decerebrate control of transmission from the FRA.
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Engberg et al. (1968) studied this question.
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