Elevation of external sodium concentration reverses the blocking action of open-channel blockers like disopyramide by decreasing the drug association rate, but does not affect inactivated-channel blockers like lidocaine.
No takes yet. Share an insight, caveat, or question.
Extracellular sodium selectively attenuates open-channel Na blocker binding in vitro; leaves open relevance to clinical antiarrhythmic efficacy.
Barber et al. (1992) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: