What question did this study set out to answer?

To evaluate primary antibiotic resistance rates in Helicobacter pylori and examine their association with annual antibiotic consumption patterns in Japan.

October 1, 2002Helicobacter

The Relationship Between Consumption of Antimicrobial Agents and the Prevalence of Primary Helicobacter pylori Resistance

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Authors

LALuis Perez AldanaBoston Graduate School of Psychoanalysis MKMototsugu KatoHakodate National Hospital SNShiori NakagawaKanazawa University

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Implication

Observational study reveals rising clarithromycin and metronidazole resistance in Japanese patients, indicating that community antibiotic consumption directly drives Helicobacter pylori drug failure.

Key Points

To evaluate primary antibiotic resistance rates in Helicobacter pylori and examine their association with annual antibiotic consumption patterns in Japan.
Tested Helicobacter pylori isolates collected from N=593 Japanese patients between 1995 and 2000, prior to the approval of eradication regimens.
Assessed susceptibility to clarithromycin, metronidazole, and amoxicillin via agar dilution, setting resistance thresholds at minimum inhibitory concentrations of >1 mg/l, >8 mg/l, and >0.5 mg/l, respectively.
Overall primary resistance across the 1995–2000 period was 11% for clarithromycin, 9% for metronidazole, and 0.3% for amoxicillin.
Resistance to clarithromycin significantly increased from 7% in 1997–1998 to 15.2% in 1999–2000 (p = .003), correlating with national antibiotic consumption.
Resistance to metronidazole significantly increased from 6.6% in 1997–1998 to 12% in 1999–2000 (p = .02), mirroring national consumption patterns.

Cite This Study

Aldana et al. (2002) studied this question.

synapsesocial.com/papers/6a7734cbc5ab23c76cec7abb https://doi.org/10.1046/j.1523-5378.2002.00096.x

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Implication

Observational study reveals rising clarithromycin and metronidazole resistance in Japanese patients, indicating that community antibiotic consumption directly drives Helicobacter pylori drug failure.

The Relationship Between Consumption of Antimicrobial Agents and the Prevalence of Primary Helicobacter pylori Resistance

Discussion

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Implication

Key Points

Cite This Study

The Relationship Between Consumption of Antimicrobial Agents and the Prevalence of Primary Helicobacter pylori Resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

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