Why the study?
This study aimed to evaluate cardiac function in a young mouse model of Duchenne muscular dystrophy using cardiac MRI with feature tracking and self-gated cine imaging.
Can cardiac MRI with feature tracking and self-gated cine imaging detect cardiac dysfunction in young mdx mice compared to controls?
Can cardiac MRI with feature tracking and self-gated cine imaging detect cardiac dysfunction in young mdx mice compared to controls?
Strain analysis with feature tracking and self-gated magnetic resonance cine imaging can successfully detect early cardiac dysfunction in young mdx mice.
Cardiac MRI strain analysis is feasible in young mdx mice; leaves open translation to DMD cardiomyopathy assessment.
This study aimed to evaluate cardiac function in a young mouse model of Duchenne muscular dystrophy (mdx) using cardiac magnetic resonance imaging (MRI) with feature tracking and self-gated magnetic resonance cine imaging. Cardiac function was evaluated in mdx and control mice (C57BL/6JJmsSlc mice) at 8 and 12 weeks of age. Preclinical 7-T MRI was used to capture short-axis, longitudinal two-chamber view and longitudinal four-chamber view cine images of mdx and control mice. Strain values were measured and evaluated from cine images acquired using the feature tracking method. The left ventricular ejection fraction was significantly less (p < 0.01 each) in the mdx group at both 8 (control, 56.6 ± 2.3% mdx, 47.2 ± 7.4%) and 12 weeks (control, 53.9 ± 3.3% mdx, 44.1 ± 2.7%). In the strain analysis, all strain value peaks were significantly less in mdx mice, except for the longitudinal strain of the four-chamber view at both 8 and 12 weeks of age. Strain analysis with feature tracking and self-gated magnetic resonance cine imaging is useful for assessing cardiac function in young mdx mice.
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Ueda et al. (2023) studied Duchenne muscular dystrophy. Duchenne muscular dystrophy (mdx) genotype vs. Control mice (C57BL/6JJmsSlc) was evaluated on Left ventricular ejection fraction at 8 weeks (p=<0.01).
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