Symmetrical anhydrides were synthesized from activated amides such as N -benzoylsaccharins and N -Boc-protected benzamides. The activated amides reacted with H 2 O in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) at 25 °C to produce the corresponding symmetrical anhydrides in high yields through C–N bond cleavage. In addition, N -benzoylsaccharins reacted with benzoic acid derivatives to generate unsymmetrical anhydrides in high yields.
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Bashir et al. (2023) studied this question.
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