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August 24, 2010CirculationOpen Access

Background, Incidence, and Predictors of Antiplatelet Therapy Discontinuation During the First Year After Drug-Eluting Stent Implantation

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Key result

Antiplatelet therapy discontinuation occurred in 14.4% of patients during the first year after drug-eluting stent implantation, with renal impairment (OR 2.81) as a significant predictor.

Why the study?

What are the incidence and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation?

Population

1,622 patients receiving at least 1 drug-eluting stent between January and April 2008 across 29 hospitals.

Design

Cohort

Follow-up

12 months

Authors

IFIgnacio Ferreira‐GonzálezCardiac ImagingJMJosep Ramón MarsalUniversitat Autònoma de BarcelonaARAída RiberaVall d'Hebron Institut de Recerca

Discussion

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Implication

Renal impairment signals need for closer adherence monitoring post-stenting; extends predictor data but leaves causal outcome impact open.

Study Design

Type

Cohort (n=1,622)

Multicenter

Yes

Structured PICO

What are the incidence and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation?

P
Population
1,622 patients who received at least one drug-eluting stent, followed prospectively for 12 months to assess predictors of antiplatelet therapy discontinuation.
E
Exposure
Antiplatelet therapy (predominantly clopidogrel)
O
Outcome
Incidence and predictors of antiplatelet therapy discontinuation (ATD) during the first year

Antiplatelet therapy discontinuation in the first year after drug-eluting stent implantation occurs in 14.4% of patients and is driven by bleeding, medical decisions, and patient-initiated factors.

Cite This Study

Ferreira‐González et al. (2010) conducted a cohort in Drug-eluting stent implantation (n=1,622). Clinical and demographic risk factors was evaluated on Antiplatelet therapy discontinuation (ATD). Antiplatelet therapy discontinuation occurred in 14.4% of patients during the first year after drug-eluting stent implantation, with renal impairment (OR 2.81) as a significant predictor.

synapsesocial.com/papers/6a7742b2d8eb58afc2bdbf54https://doi.org/10.1161/circulationaha.110.938290

Topics

Dual antiplatelet therapyCoronary artery disease
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