Key result
UTP significantly increased spreading (6.8-fold; P<=0.01) and migration (3.6-fold; P<=0.01) of wild-type aortic smooth muscle cells compared with unstimulated cells via P2Y2R/FLNa interaction.
Population
Aortic smooth muscle cells (SMCs) isolated from wild-type and P2Y2R knockout mice, and yeast 2-hybrid system
Comparison
UTP and ATP and transfection with full-length or… vs Unstimulated SMCs and SMCs from P2Y2R knockout…
Design
Preclinical
Authors
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P2Y2R/FLNa interaction may regulate SMC motility in vascular remodeling; leaves open therapeutic targeting pending in vivo confirmation.
Effect estimate: 6.8 fold increase in spreading; 3.6 fold increase in migration
p-value: p=<=0.01
The interaction between the P2Y2 nucleotide receptor and filamin A selectively regulates the spreading and migration of vascular smooth muscle cells.
Yu et al. (2008) studied Atherosclerosis and restenosis. UTP (P2Y2R agonist) vs. Unstimulated SMCs / P2Y2R knockout cells was evaluated on SMC spreading on collagen I and migration (6.8 fold increase in spreading; 3.6 fold increase in migration, p=<=0.01). UTP significantly increased spreading (6.8-fold; P<=0.01) and migration (3.6-fold; P<=0.01) of wild-type aortic smooth muscle cells compared with unstimulated cells via P2Y2R/FLNa interaction.
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