Among 219 operations for colloid goiter and benign tumors I had two deaths, one from suppression of urine, the other from myocarditis after healing had occurred. I shall not allude to the malignant and infection cases. My study is of 121 operative eases of exophthalmic goiter, particularly an inquiry into the cause of operative hyperthyroidism, and into the development of a safer technic. CHANGES IN THE BRAIN CELLS IN A CASE OF GRAVES' DISEASE In a case of Graves' disease, the patient being unoperated on and free from infection, which ran a natural course to its termination in death, a pathologic examination of the brain and cord was made by Dr. J. B. Austin. The following is his summary: In the cord but slight changes were seen; in the medulla there was considerable chromatolysis, the Nissl granules were in moderately fine division, and the nucleus plasma relation was changed; in
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G. W. Crile (1911) studied this question.