Resolving complex systems: The formation of a dynamic hemithioacetal system and its application toward the discovery of β-galactosidase inhibitors were successfully investigated. The designed dynamic system, which has a virtual character in neutral aqueous media, was subjected to a direct in situ identification of the best inhibitors by 1H STD NMR spectroscopy (ONPG: o-nitrophenyl-β-galactopyranoside).
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Caraballo et al. (2009) studied this question.
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