Key result
Amifostine administration 30 minutes prior to cardiac radiotherapy did not reduce acute pericardial inflammation compared to radiotherapy alone in an experimental rat model.
Why the study?
Data were lacking on the use of amifostine to prevent acute pericardial damage caused by radiotherapy.
Does amifostine prevent radiotherapy-induced acute pericarditis in a rat model?
Does amifostine prevent radiotherapy-induced acute pericarditis in a rat model?
Amifostine administration prior to cardiac radiotherapy does not protect against acute pericardial inflammation in a rat model.
Answers are grounded in this paper and cite their sources.
Amifostine shows no protection against acute pericarditis in this rat model; leaves open any role in human radiotherapy.
BACKGROUND: Amifostine is a powerful antioxidant that is one of the documented three chemo-radio prototectants recommended for clinical use. There is no data exploring amifostine in prevention of acute pericardial damage. We aimed to investigate whether amifostine has protective effect against acute pericardial injury due to radiotherapy in an experimental rat model. METHODS: Twenty-four rats were divided into four groups: control group, radiotherapy-only group, amifostine-only group, radiotherapy+amifostine group. In groups receiving radiotherapy, hearts were irradiated with a Co 60 teletherapy device at a distance of 80 cm and 20 Gy at a depth of 2 cm. Thirty minutes before interventions, 200 mg/kg amifostine or same volume 0.9% NaCl were administered intraperitoneally. Subjects were sacrificed 24 hours after the procedure. Pericardial histopathological changes were investigated by light microscopy. RESULTS: There was focal inflammation of >= 50% in all rats exposed-to-radiotherapy. All groups receiving radiotherapy revealed a significant increase in pericardial inflammation compared to the groups that did not receive irradiation (p<0.05). There was no difference between the radiotherapy-only group and amifostine+radiotherapy group for pericardial inflammatory response (p>0.05). CONCLUSION: Acute pericarditis was detected in all rats receiving radiotherapy. There was no positive effect of amifostine administration before radiotherapy on acute pericardial inflammation.
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Bahat et al. (2022) studied Radiotherapy-induced acute pericarditis (n=24). Amifostine vs. Radiotherapy only (0.9% NaCl) was evaluated on Pericardial inflammatory response (p=>0.05). Amifostine administration 30 minutes prior to cardiac radiotherapy did not reduce acute pericardial inflammation compared to radiotherapy alone in an experimental rat model.
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