A Review of Gout Flare Management

Summary Gout flares are sudden, intensely painful inflammatory episodes triggered by the accumulation of monosodium urate crystals in the joints. Management aims to reduce inflammation and relieve pain, with non-steroidal anti-inflammatory agents (NSAIDs), corticosteroids, and colchicine used as first line treatment options. Recent Findings Since these therapies have shown similar efficacy, the choice among them depends on individual patient factors such as comorbid conditions, medication interactions, drug availability, and potential side effects. In cases where standard treatments are non-effective or contraindicated, newer alternatives including IL-1β inhibitors or dapansutride are increasingly being studied. Purpose of Review This review will discuss current approaches to gout flare management, with particular focus on different clinical scenarios where gout coexists with comorbidities including chronic kidney disease, cardiovascular disease, diabetes, and infection.