Why the study?
Does antiplatelet drug discontinuation affect the timing and risk of ischemic stroke?
Does antiplatelet drug discontinuation affect the timing and risk of ischemic stroke?
Ischemic strokes related to antiplatelet drug discontinuation exhibit a highly specific temporal pattern, occurring 6 to 10 days after disruption.
APD discontinuation may associate with ischemic stroke at 6-10 days; leaves open causal mechanisms and practice implications.
Antiplatelet drugs (APD) are widely used in the prevention of ischemic cardio- and cerebrovascular diseases. The authors studied the frequency of stroke occurring after APD discontinuation, the cause of discontinuation, and the delay between APD disruption and stroke. Only 4.49% of strokes were related to a recent APD discontinuation, but all cases occurred between 6 and 10 days after drug discontinuation (p < 0.0001). This temporal pattern has biologic plausibility because the inhibited platelets circulate in the blood for about 10 days.
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Sibon et al. (2004) studied this question.
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