Experimental study reveals focal central nervous system penetration of amphotericin B in fungal meningoencephalitis models, highlighting how localized barrier breakdown enables drug efficacy.
Hematogenous Candida meningoencephalitis (HCME) is a life-threatening complication of neonates and immunocompromised children. Amphotericin B (AmB) shows poor permeation and low cerebrospinal fluid (CSF) concentrations but is effective in the treatment of HCME. In order to better understand the mechanism of CNS penetration of AmB, we hypothesized that AmB may achieve focally higher concentrations in infected CNS lesions.
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Petraitis et al. (2019) studied this question.
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