What question did this study set out to answer?

To determine how the Marburg I (G534E) polymorphism of factor VII-activating protease impacts neointima formation and smooth muscle accumulation following vascular injury.

December 4, 2006The Journal of Experimental MedicineOpen Access

The G534E polymorphism of the gene encoding the factor VII–activating protease is associated with cardiovascular risk due to increased neointima formation

View Full Paper

Ask AI

Bookmark

Authors

DSDaniel SeddingMartin Luther University Halle-Wittenberg JDJan‐Marcus DanielUniversity Hospital in Halle LMLars MuhlKarolinska Institutet

Discussion

Member takes

Implication

Experimental study reveals that the Marburg I FSAP variant fails to inhibit arterial neointima formation in mice, indicating a molecular mechanism for heightened cardiovascular risk.

Key Points

To determine how the Marburg I (G534E) polymorphism of factor VII-activating protease impacts neointima formation and smooth muscle accumulation following vascular injury.
Assessed wire-induced femoral artery injury in a mouse model following local administration of wild-type or Marburg I factor VII-activating protease.
Evaluated the proteolytic cleavage activity of wild-type versus Marburg I variants against platelet-derived growth factor BB.
Local application of wild-type factor VII-activating protease reduced neointima formation by 70% in a protease-dependent manner, whereas the Marburg I variant produced no in vivo inhibition.
Marburg I factor VII-activating protease demonstrated reduced proteolytic cleavage of platelet-derived growth factor BB, failing to suppress vascular smooth muscle cell accumulation.

Cite This Study

Sedding et al. (2006) studied this question.

synapsesocial.com/papers/6a778126c5ab23c76cecb110 https://doi.org/10.1084/jem.20052546

View Full Paper

Ask AI

Bookmark

Implication

Experimental study reveals that the Marburg I FSAP variant fails to inhibit arterial neointima formation in mice, indicating a molecular mechanism for heightened cardiovascular risk.

The G534E polymorphism of the gene encoding the factor VII–activating protease is associated with cardiovascular risk due to increased neointima formation

Discussion

Member takes

Implication

Key Points

Cite This Study

The G534E polymorphism of the gene encoding the factor VII–activating protease is associated with cardiovascular risk due to increased neointima formation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider