April 1, 1997Circulation
Interrelation of Hyperhomocyst(e)inemia, Factor V Leiden, and Risk of Future Venous Thromboembolism
Key result
Coexistent hyperhomocysteinemia and factor V Leiden linked to ~22-fold higher risk of idiopathic VTE.
- RR 21.8
- P=.0004
- n=791
Why the study?
Patients with rare familial homocystinuria who also carry factor V Leiden have increased VTE incidence, suggesting a possible interrelation of moderate hyperhomocyst(e)inemia, factor V Leiden, and VTE risk in the general population.
Does the coexistence of hyperhomocyst(e)inemia and factor V Leiden mutation increase the risk of future venous thromboembolism in initially healthy men?
Comparison
Men with hyperhomocyst(e)inemia and/or factor V Leiden mutation vs men without these abnormalities
Design
Large prospective cohort study
Follow-up
10-year
Authors
Discussion
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Member takes
Implication
May identify high-risk men for VTE surveillance; leaves open whether screening or intervention improves outcomes.
Study Design
Type
Cohort (n=791)
Structured PICO
Does the coexistence of hyperhomocyst(e)inemia and factor V Leiden mutation increase the risk of future venous thromboembolism in initially healthy men?
P
Population
791 initially healthy men followed for 10 years to assess the risk of future venous thromboembolism.
E
Exposure
Presence of hyperhomocyst(e)inemia (total homocysteine >17.25 mumol/L) and/or factor V Leiden mutation
C
Comparator
Men with normal total homocysteine levels and without factor V Leiden mutation
O
Outcome
Development of any venous thromboembolism (VTE) or idiopathic VTE over a 10-year follow-up periodhard clinical
Main Result
Relative Risk: 21.8
p-value: p=.0004
The coexistence of hyperhomocyst(e)inemia and factor V Leiden mutation synergistically increases the risk of future venous thromboembolism in apparently healthy men.
Cite This Study
Ridker et al. (1997) conducted a cohort in Venous Thromboembolism (n=791). Coexistent hyperhomocyst(e)inemia and factor V Leiden mutation vs. Men with neither abnormality was evaluated on Idiopathic VTE (RR 21.8, p=.0004). Coexistent hyperhomocyst(e)inemia and factor V Leiden mutation in healthy men was associated with a 20-fold increased risk of idiopathic VTE compared to neither abnormality (RR 21.8, P=0.0004).