Determination of antidiabetic activity by cell line method is one of the foremost techniques compared to in vivo animal model. It is fruitful in determining the mechanism of drugs. The RINm5F cells are considered to produces insulin and it is one of most widely used insulin-secreting cell lines. In the present study, we assessed the defensive property of Pleurotus ostreatus against RINm5F cells. The apoptosis of RINm5F cells were determined by providing the cell with ethanol extract of P. ostreatus in presence of streptozotocin (STZ). The STZ treated group significantly increases the apoptotic population compared to the normal group. The extract treated RINm5F cells manifested the decline in apoptotic population resembled to STZ treated RIN cells. The present study scientifically supported the protective effects of the P. ostreatus against the oxidative damage induced by STZ.
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Roy et al. (2014) studied this question.