Key result
Natriuretic peptides play a significant role in the development of the fetal heart and circulation, and are implicated in various cardiovascular diseases of the neonatal and pediatric age groups.
This review highlights the critical role of natriuretic peptides in fetal cardiac development and their relevance in neonatal and pediatric cardiovascular diseases.
Warrants biomarker exploration in neonatal cardiology; leaves open therapeutic targeting pending prospective trials.
The natriuretic peptides (NP) appear to be functional by midgestation, respond to volume stimuli, and regulate blood pressure and salt and water balance in the developing embryo. In addition, the NP may help regulate the blood supply to the fetus, acting as vasodilators in the placental vasculature. Peaks of ANP and BNP expression during gestation coincide with significant events in cardiac organogenesis, suggesting a role for NP in the formation of the heart. Levels of atrial natriuretic peptide (ANP) are higher in the fetal circulation than in adults, and fetal ventricles express higher levels of ANP and B-type natriuretic peptide (BNP) than adult ventricles. In this comprehensive review we have discussed the role NP during development of the fetal heart and circulation and in various cardiovascular diseases of neonatal and pediatric age group.
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Das et al. (2009) conducted a review in Cardiovascular diseases of fetus, infants and children. Natriuretic peptides was evaluated. Natriuretic peptides play a significant role in the development of the fetal heart and circulation, and are implicated in various cardiovascular diseases of the neonatal and pediatric age groups.
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