The effects of three glycosaminoglycans (chondroitin 6‐sulfate, dermatan sulfate, and hyaluronate) and a proteoglycan on the kinetics of fibril formation and on the thermal stability of the in vitro assembled collagen fibrils, under physiological conditions of ionic strength and pH, have been examined. The glycosaminoglycans were found to influence the kinetics of collagen precipitation but not the thermal stability of the in vitro assembled fibrils. The proteoglycan was found to influence the kinetics of collagen precipitation and to reduce the thermal stability of the in vitro assembled fibrils. Comparison of the interaction occurring between chondroitin 6‐sulfate and collagen under acidic conditions (0.05 M acetic acid) and that occurring under physiological conditions showed that markedly different interaction products were formed under the different conditions.
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Snowden et al. (1980) studied this question.
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