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Provides molecular context for isoform shifts; leaves open whether targeting them improves heart failure outcomes.
Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.
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Kitsis et al. (1996) studied this question.
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