Key result
Levosimendan was superior to nitroglycerin in improving diastolic function parameters, including isovolumic relaxation time (P=0.0001) and deceleration time (P=0.0001), in patients undergoing CABG.
Why the study?
Does levosimendan improve diastolic function compared to nitroglycerin in patients with isolated diastolic dysfunction undergoing coronary artery bypass grafting?
RCT (n=30)
Randomized into 2 groups
Does levosimendan improve diastolic function compared to nitroglycerin in patients with isolated diastolic dysfunction undergoing coronary artery bypass grafting?
p-value: p=0.0001
Levosimendan is superior to nitroglycerin in improving diastolic function in patients with isolated diastolic dysfunction undergoing coronary artery bypass grafting.
Authors
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Supports levosimendan over nitroglycerin for diastolic dysfunction in CABG; extends randomized evidence to isolated diastolic dysfunction.
Malik et al. (2015) conducted an RCT in Isolated diastolic dysfunction (n=30). Levosimendan vs. Nitroglycerin was evaluated on Diastolic function (isovolumic relaxation time and deceleration time) (p=0.0001). Levosimendan was superior to nitroglycerin in improving diastolic function parameters, including isovolumic relaxation time (P=0.0001) and deceleration time (P=0.0001), in patients undergoing CABG.