May 15, 1999Journal of NeuroscienceOpen Access

Contributions of the Brain Angiotensin IV–AT₄Receptor Subtype System to Spatial Learning

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Structured PICO

Population

Male Sprague Dawley rats (270–350 gm), n=80 (24 in experiment 1, 24 in experiment 2, 32 in experiment 3)

Intervention

Intracerebroventricular infusion of AT4 receptor agonist (Nle1-AngIV 0.1 or 0.5 nmol/hr, or Norleucinal) or AT4 receptor antagonist (Divalinal 0.5 or 5.0 nmol/hr) via osmotic pump or acute injection

Comparator

Artificial CSF (aCSF), non-treated control, or pentapeptide AngII(4-8) 0.5 nmol/hr

Outcome

Latency and path distance to find a submerged pedestal in a circular water mazesurrogate

Activation of the brain AngIV-AT4 receptor system facilitates spatial learning and memory acquisition in rats, while its antagonism impairs it.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Animal data link AngIV-AT4 signaling to spatial learning; leaves open any human cognitive applications.

Cite This Study

Wright et al. (1999) studied this question.

synapsesocial.com/papers/6a779cde6789de8d0af7521f https://doi.org/10.1523/jneurosci.19-10-03952.1999

View Full Paper

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Contributions of the Brain Angiotensin IV–AT₄Receptor Subtype System to Spatial Learning

Structured PICO

Discussion

Implication

Cite This Study

Contributions of the Brain Angiotensin IV–AT₄Receptor Subtype System to Spatial Learning

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider