Why the study?
Does hypothermia alter heparin anticoagulation as measured by ACT and anti-factor Xa assay in adult patients undergoing cardiopulmonary bypass?
Population
17 adult patients with normal blood coagulation function undergoing their first time coronary artery bypass…
Comparison
Hypothermia during cardiopulmonary bypass vs Before cooling during cardiopulmonary bypass
Design
Cohort
Follow-up
During cardiopulmonary bypass (before and after cooling)
Authors
Loading...
ACT prolongation during hypothermic CPB may not reflect true heparin levels; leaves open whether temperature-adjusted ACT targets are warranted.
Does hypothermia alter heparin anticoagulation as measured by ACT and anti-factor Xa assay in adult patients undergoing cardiopulmonary bypass?
Hypothermia during cardiopulmonary bypass prolongs activated clotting time without changing actual heparin concentration, indicating ACT may be unreliable for trending heparin levels during cooling.
Tian et al. (1995) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: