Giving a one-two punch: A bicyclam-based biodegradable polycation with CXCR4 antagonistic activity shows potential for combining cancer chemotherapy with gene therapy or siRNA therapy. This dual-function polycation prevents cancer cell invasion by inhibiting CXCL12-stimulated CXCR4 activation (see scheme), while at the same time efficiently and safely delivering therapeutic DNA into cancer cells.
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Li et al. (2012) studied this question.
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