Rearranging complexity: The total synthesis of resveratrol dimers hopeanol (1) and hopeahainol A (2, see scheme) is described. By using a reagent-driven pinacol rearrangement coupled with specific oxidation chemistry, the frameworks are constructed concisely and on scale. Moreover, the route has biogenetic implications that trace the origin of these compounds to more common dimeric family members.
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Snyder et al. (2012) studied this question.
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