July 8, 2009Organic Letters

Highly Enantioselective Synthesis of β-Amidophenylthioethers by Organocatalytic Desymmetrization of meso-Aziridines

View Full Paper

Ask AI

Bookmark

Authors

GSGiorgio Della SalaUniversity of Salerno ALAlessandra LattanziUniversity of Salerno

Abstract

The desymmetrization of N-acylaziridines with Me(3)SiSPh, catalyzed by commercially available (R) and (S)-VAPOL hydrogen phosphate, produced beta-(N-acylamino)phenylthioethers in a highly enantioselective and efficient manner (78-99% ee). The selection of the suitable aziridine/nucleophile/catalyst molar ratio is crucial to obtain high ee's.

Discussion

Member takes

Cite This Study

Sala et al. (2009) studied this question.

synapsesocial.com/papers/6a77b15c4fe2e6ffd8ece098 https://doi.org/10.1021/ol901209n

View Full Paper

Ask AI

Bookmark

Highly Enantioselective Synthesis of β-Amidophenylthioethers by Organocatalytic Desymmetrization of meso-Aziridines

Abstract

Discussion

Member takes

Cite This Study

Highly Enantioselective Synthesis of β-Amidophenylthioethers by Organocatalytic Desymmetrization of meso-Aziridines

Abstract

Discussion

Member takes

Cite This Study

Also Consider

Also Consider