Advances in Controlled Oxygen Generating Biomaterials for Tissue Engineering and Regenerative Therapy

Oxygen (O 2 ) generating biomaterials are emerging as important compositions to improve our capabilities in supporting tissue engineering and regenerative therapeutics. Several in vitro studies demonstrated the usefulness of O 2 releasing biomaterials in enhancing cell survival and differentiation. However, more efforts are needed to develop materials that can provide sustained O 2 release for the long-term. In this paper, we present different O 2 generating sources, including hydrogen peroxide, sodium percarbonate, calcium peroxide and magnesium peroxide, and also cover types of carriers and relevant methods of fabricating O 2 generating systems. Then, the applications of O 2 generating materials in supporting engineered constructs, supplying high O 2 demanding cell transplants, and supporting ischemic tissues are discussed. Moreover, the challenges and future perspectives are highlighted.