Why the study?
Do drug-coated stents prevent restenosis after coronary angioplasty?
Do drug-coated stents prevent restenosis after coronary angioplasty?
Drug-coated stents are a promising approach to prevent restenosis after coronary angioplasty by suppressing remodeling and neointimal hyperplasia.
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Drug-coated stents may aid restenosis prevention; leaves open confirmation in randomized trials before practice change.
Drug-coated stents appear to be the most promising approach among all interventional strategies to prevent restenosis. These stents both suppress geometric remodeling and inhibit neointimal hyperplasia with a therapeutic agent. Animal studies and recent randomised clinical trials with sirolimus-eluting stents have achieved excellent results in the prevention of restenosis. These stents also have a good safety record and demonstrate a durable clinical benefit for patients at long-term follow-up. This article summarises experimental and clinical experiences with local drug delivery via a stent coating in the prevention of restenosis after coronary angioplasty, outlining the clinician's view of current trends.
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Poerner et al. (2002) studied this question.
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