Why the study?
Are elevated STAB1 levels associated with atherosclerotic plaque burden and dysregulated lipid metabolism in individuals with and without T2DM?
Are elevated STAB1 levels associated with atherosclerotic plaque burden and dysregulated lipid metabolism in individuals with and without T2DM?
STAB1 may serve as a potential circulating indicator of atherosclerotic burden in the general population and individuals with T2DM.
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STAB1 may mark plaque burden but should not yet inform clinical decisions; leaves open its value as a circulating biomarker.
Stabilin-1 (STAB1) and Stabilin-2 (STAB2) are scavenger receptors involved in the clearance of oxidized LDL cholesterol. This study demonstrates that in a cohort of individuals with and without type 2 diabetes mellitus (T2DM), elevated STAB1 levels are associated with high atherosclerotic plaque burden and dysregulated lipid metabolism. These findings highlight STAB1 as a potential circulating indicator of the atherosclerotic burden in the general population, as well as in individuals with T2DM.
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Giannousi et al. (2025) studied this question.
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