Are elevated STAB1 levels associated with atherosclerotic plaque burden and dysregulated lipid metabolism in individuals with and without T2DM?
STAB1 may serve as a potential circulating indicator of atherosclerotic burden in the general population and individuals with T2DM.
Stabilin-1 (STAB1) and Stabilin-2 (STAB2) are scavenger receptors involved in the clearance of oxidized LDL cholesterol. This study demonstrates that in a cohort of individuals with and without type 2 diabetes mellitus (T2DM), elevated STAB1 levels are associated with high atherosclerotic plaque burden and dysregulated lipid metabolism. These findings highlight STAB1 as a potential circulating indicator of the atherosclerotic burden in the general population, as well as in individuals with T2DM.
Giannousi et al. (Wed,) studied this question.