In a small cleaved, follicular center cell (poorly differentiated) lymphoma the majority of the cells appeared vacuolated by light microscopy. This is an example of the recently described signet-ring cell lymphoma. Immunoperoxidase staining demonstrated that the cells contained IgG/k. Ultrastructural observations indicated that small vacuoles coalesce to form the large vacuoles, which contain microvesicles approximately 50 nm in diameter.
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Iossifides et al. (1980) studied this question.
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